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Tadalafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) used to treat erectile dysfunction, pulmonary hypertension, and 

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Tadalafil is a PDE-5 inhibitorwith IC50 of 1.8 nM in a cell-free assay. This compound is at least 9000 times more selective for PDE5 than most of the other 
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